The manifestations of MF, post-PV-MF and post-ET-MF are virtually identical and treatment is generally the same for all three. As a result, it becomes more difficult for the bone marrow to create normal blood cells and blood cell production may move to the spleen (causing enlargement) or to other areas of the body.Ĭlassified as a myeloproliferative neoplasm (MPN), MF can arise on its own or as a progression of polycythemia vera (post-PV-MF) or essential thrombocythemia (post-ET-MF). The abnormal stem cells produce mature cells that grow quickly and take over the bone marrow, causing both fibrosis (scar tissue formation) and chronic inflammation. Researchers believe MF may be caused by abnormal blood stem cells in the bone marrow. Primary myelofibrosis (MF) is a chronic blood cancer in which excessive scar tissue forms in the bone marrow and impairs its ability to produce normal blood cells.
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